By H. Kalant (auth.), Milton M. Gross (eds.)
The contributions to this quantity in actual fact point out the momentum, caliber, liveliness and variety of the study attempt being di rected towards deepening our realizing of tqe alcohol withdrawal syndrome. This zone of research has received expanding curiosity and a focus to the purpose the place it appeared average to commit a spe cial part to it on the thirtieth overseas Congress for Alcoholism and Drug Dependence in Amsterdam in September, 1972. Our objective used to be to proportion our latest findings and stimulate others to affix within the attempt. With few exceptions, the papers during this booklet current new facts. It were was hoping that the amount would seem via the tip of 1972. besides the fact that, the passion of a number of the participants to increase their investigations made this objective date very unlikely. a number of of the papers weren't awarded within the part yet have been provided somewhere else within the Congress. besides the fact that, as a result of their specific relevance to the subject they've been integrated with the beneficiant consent of the authors.
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Additional info for Alcohol Intoxication and Withdrawal I: Experimental Studies
It has been established that reuptake is a major mechanism for limiting the action of neuronally secreted NE (Axelrod, 1971). Because of this, uptake in vivo has become a tool for evaluating putative and false neurotransmitters. L FIGURE 4. ELECTRON MICROGRAPH OF A SYMPATHETIC BOUTON SHOWING VESICLES FILLED WITH 6,7-DIHYDROXY-TIQ. In this experiment, rabbits were treated with reserpine in order to deplete the endogenous NE content of the sympathetic nerves. 4 buffer at 37°C for 30 minutes (controls) or in buffer containing 5 x 10-3M TIQ.
Goldstein and Judson (23), in addition, were unable ADDICTION TO BARBITURATES AND ETHANOL 47 to produce withdrawal symptoms by administration of naloxone (a morphine antagonist) to mice "addicted" (24) to ethanol. THP, however, has pharmacologic properties (l3-adrenergic) (25) not dependent on its conversion to the opiates, and the condensation products of both dopamine and norepinephrine with acetaldehyde per se have been shown to displace the catecholamines from CNS storage sites and compete with them for the re-uptake mechanism (26).
In connection with the slowing of the rate of development of tolerance and dependence when we pass from the mouse to the rat and from the rat to man, it deserves note that the adaptive increase in mitochondrial ~-hydroxybutyrate dehydrogenase activity requires 2 days in the rat and some weeks in man (McIlwain, 1971). The rates of these processes seem to reflect general differences in the intensity of metabolic reactions which accompany changes in body size. The fact that tolerance develops with alcohol doses sufficiently spaced to permit complete elimination before renewed administration, whereas marked signs of dependence are seen only after prolonged intoxication, suggests that the mechanisms underlying the two phenomena are different.
Alcohol Intoxication and Withdrawal I: Experimental Studies by H. Kalant (auth.), Milton M. Gross (eds.)