By Douglas W. P. Hay (auth.), Dr. David Raeburn, Dr. Mark A. Giembycz (eds.)
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Additional info for Airways Smooth Muscle: Peptide Receptors, Ion Channels and Signal Transduction
J. Cardiovasc. Pharmacol. 1993; 22 (Suppl. 8): S117-20. 129. Power RF, Wharton J, Zhao Y, Bloom SR, Polak JM. Autoradiographic localization of endothelin-l binding sites in the cardiovascular and respiratory systems. J. Cardiovas. Pharmacol. 1989; 13 (Suppl. 5): S50-6. 130. Turner NC, Power RF, Polak JM, Bloom SR, Dollery CT. Endothelin-induced contractions of tracheal smooth muscle and identification of specific endothelin binding sites in the trachea of the rat. Br. J. Pharmacol. 1989; 98: 361-6.
Can be addressed satisfactorily. Thus, considerable work, in particular using human isolated tissues, and in the clinical setting with ET receptor antagonists and/or EeE inhibitors remains before a definitive link can be established between the ETs and the pathophysiology of asthma. 3. Pulmonary Hypertension Pulmonary hypertension is a progressively deteriorating condition characterized by an increase in vascular tone and vasoreactivity and enhanced proliferation of smooth muscle cells, resulting in a significant elevation in pulmonary vascular resistance, which leads to right-heart failure and death.
Cardiovasc. Pharmacol. 1989; 13 (Suppl. 5): S5-S7. 32. Opgenorth TJ, Wu-Wong JR, Shiosaki K. Endothelin-converting enzymes. FASEB J. 1992; 6: 2653-9. 33. Takaoka M, Shiragami K, Fujino K, Miki K, Miyake Y, Yasuda M et at. Phosphoramidon-sensitive endothelin converting enzyme in rat lung. Biochem. Internat. 1991; 25: 697-704. 34. Sawamura, T, Shinmi 0, Kishi N, Sugita Y, Yanagisawa M, Goto K el ai. Characterization of phosphoramidon-sensitive metalloproteinases with endothelin-converting enzyme activity in porcine lung membrane.
Airways Smooth Muscle: Peptide Receptors, Ion Channels and Signal Transduction by Douglas W. P. Hay (auth.), Dr. David Raeburn, Dr. Mark A. Giembycz (eds.)