By Shane Crotty
In Fifties, Watson and Crick confirmed a so-called "central dogma" in molecular biology: DNA makes RNA, and RNA makes proteins. even though, round 1970, teams in US chanced on the 1st exception of this rule. David Baltimore's and Howard Temin's groups found that RNA makes DNA! This unforeseen discovering of theirs in cancer-causing RNA viruses not just made this box up-side down, but in addition opened a brand new street referred to as "recombinant expertise" a decade later, for cloning genes and transfering any gene from one species to a different virtually at will. accordingly, Baltimore and Temin shared a Nobel prize in 1975. Baltimore's greatness prolonged past the technological know-how. He considered this international in an "unconventional" demeanour. He married a highly-talented chinese language biologist, and protested opposed to the hugely debatable US wars in Vietnam and Iraq. He has a good knowledge which shall we study from this well-written biography.
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Extra info for Ahead of the Curve: David Baltimore's Life in Science
Darnell didn’t think he could use Baltimore, so he turned him down. Baltimore was mortified. Darnell’s rejection meant that he couldn’t do animal virology at MIT. Fortunately, Richard Franklin was interested by Baltimore’s curiosity and intelligence from their daily interactions at the lab bench. The two hit it o¤, and Franklin told Baltimore that he could join his animal virology lab at the Rockefeller Institute in Manhattan. ” When Baltimore returned to MIT in August he told Luria all that had transpired; he wanted to transfer to Rockefeller.
The course was a revelation. ” At Cold Spring Harbor Baltimore ran into Jim Darnell, who was attending one of the summer conferences. Baltimore introduced himself and asked to join Darnell’s MIT laboratory in the fall. Darnell hesitated. He was a young scientist, and this professorship at MIT would be his first experience of running a lab. He didn’t know Baltimore, and he was already bringing someone else to work with him. Darnell didn’t think he could use Baltimore, so he turned him down. Baltimore was mortified.
Franklin’s laboratory consisted of Franklin himself, a technician, and Baltimore, all carefully pulling viruses apart, handling up to a trillion viruses a day. O‹cially, Franklin worked for Igor Tamm, the full professor who ran the animal virology laboratory. Rockefeller was arranged like a European university, with a full professor overseeing the work of a group of junior professors. Almost all other American universities allowed junior professors to run their own laboratories freely. Franklin worked hard, but it was Baltimore who spent nights working alone, one of a few scientists in the dark high-rise, tending to cells and protein extracts with stubborn vigilance.
Ahead of the Curve: David Baltimore's Life in Science by Shane Crotty