By Ramana S. Moorthy, MD
A dialogue of the medical method of uveitis results in largely rewritten chapters on noninfectious (autoimmune) and infectious types of uveitis. additionally coated are endophthalmitis, masquerade syndromes, and problems of uveitis. A dialogue on ocular involvement in AIDS has been up to date. The part on immunology describes the human immune reaction in phrases that make it hugely obtainable to readers.
Read or Download 2008-2009 Basic and Clinical Science Course: Section 9: Intraocular Inflammation and Uveitis (Basic and Clinical Science Course 2008-2009) PDF
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Additional resources for 2008-2009 Basic and Clinical Science Course: Section 9: Intraocular Inflammation and Uveitis (Basic and Clinical Science Course 2008-2009)
It is composed of 2 layers: an epithelial layer and a connective tissue layer called the substantia propria. The conjunctiva is wellvascularized and has good lymphatic drainage to preauricular and submandibular nodes. The tissue is richly invested with Langerhans cells, other dendritic cells, and macrophages that serve as potential antigen-presenting cells (APCs). Conjunctival follicles that enlarge after certain types of ocular surface infection or inflammation represent collections of T lymphocytes, B lymphocytes, and APCs.
In mice with fetal retinal grafts, immune rejection occurs by an unusual, slowly progressive cytotoxic mechanism not involving typical antibody-mediated cytolysis or DH T lymphocytes. In humans and nonhuman primates, rejection of RPE allografts has occurred in both subacute and chronic forms. Retinal gene therapy Retinal gene therapy is the therapeutic use of intentional transfection of photoreceptors or RPE with a replication-defective virus that has been genetically altered to carry a replacement gene of choice.
39 Corneal edema Khodadoust rejection line Figure3-2 Endothelial graft rejection with stromal and epithelial edema on the trailing aspect of the migrating Khodadoust line. avascular cornea. Another factor is the presence of intact immunoregulatory systems of the anterior chamber (ie, ACAID), to which the corneal endothelium is exposed. See Clinical Example 3-3. CLINICAL EXAMPLE 3-3 Corneal allograft rejection Penetrating keratoplasty, the transplantation of foreign corneal allografts, enjoys an extremely high success rate (>90%) even in the absence of systemic immunomodulation.
2008-2009 Basic and Clinical Science Course: Section 9: Intraocular Inflammation and Uveitis (Basic and Clinical Science Course 2008-2009) by Ramana S. Moorthy, MD